HDAC3 and acute kidney injury: Additionally, in mouse kidneys with acute kidney injury (AKI) induced by aristolochic acid I or folic acid, marked tubule ferroptosis with GPX4 transcriptional suppression and preferential histone deacetylase HDAC3 elevation occurs; however, the HDAC3 inhibitor RGFP966 GPX4 restoration-sensitively alleviates the ferroptotic pathologies [34].