GPX4 and early-onset autosomal dominant Alzheimer disease: For example, in the mouse brain of Alzheimer’s disease model, neuronal GPX4 suppression and ferroptosis are accompanied by repression of peroxisome proliferative-activated receptor-α (PPAR-α), while the PPAR-α agonist GW7647 effectively reverses GPX4 transcriptional suppression and improves brain ferroptotic injuries [33].