IL6 and rheumatoid arthritis: In early RA, Th17 cell numbers correlate with disease activity, and nucleotide oligodomain (NOD)-like receptor 12 (NLRP12), an inhibitor, negatively regulates IL-6-induced STAT3 phosphorylation in T cells, decreasing Th17 cell differentiation and abrogating hyperinflammatory arthritis (113).