For example, previous studies have shown that inhibition of BET proteins by JQ1 and I-BET151 or selective BRD4-degrader proteolysis targeting chimera (PROTAC) (ARV-825) leads to an increase in the expression of NKG2D ligand MICA in multiple myeloma (MM) cell lines [RPMI-8226, U266, ARP-1, JJN3, SKO-007(J3)] isolated from MM patients and CD138+ MM cells. This evidence concerns the gene MICA and Miyoshi myopathy.