Mohamed et al. (2021) demonstrated that midbrain organoids generated from PD-iPSCs carrying an SNCA triplication recapitulate key synucleinopathy features such as the accumulation of α-synuclein aggregates and the degeneration of dopaminergic neurons. Jo et al. (2021) investigated midbrain organoids derived from hiPSCs carrying mutations in both the glucocerebrosidase and SNCA genes. Here, SNCA is linked to Parkinson disease.