CACNA2D2 and Epileptic encephalopathy: Several genes encoding VGCC subunits have been associated with epileptic encephalopathy, including CACNA1A (Epi, 2016; Epi et al., 2013; Niu et al., 2022), CACNA1C (Bozarth et al., 2018), CACNA1E (Helbig et al., 2018), CACNA2D1 (Dahimene et al., 2022), and CACNA2D2 (Table 1).