To date, five cases of infantile‐onset epilepsy and cerebellar atrophy linked to bi‐allelic mutations in CACNA2D2 have been reported in unrelated families (Table 1; Butler et al., 2018; Edvardson et al., 2013; Pippucci et al., 2013; Punetha et al., 2019). This evidence concerns the gene CACNA2D2 and Cerebellar atrophy.