Notably, members of the CXC chemokine family, including CXCL1, CXCL2, CXCL3, CXCL5 and CXCL8, function through the activation of CXCR1 and CXCR2, playing a key role in promoting tumour angiogenesis.24 The gene discussed is CXCL2; the disease is neoplasm.