Based on the effects of NKG2D CAR and IL-15/IL-15Rα on virus-infected cells and tumor cells, as well as the NKG2DL expressions on B-LCL cells of EBV-PTLD mouse models, we propose IL-15/IL-15Rα co-expressing NKG2D CAR-T for the treatment of EBV PTLD - an approach that has not been reported thus far. This evidence concerns the gene IL15 and neoplasm.