TP53 and neoplasm: TRIM28 interacts with RLIM, which interacts with MDM2 to promote its degradation, to further enhance its ubiquitination, thereby ensuring low levels of p53 expression and promoting tumor cell proliferation and survival of lung cancer cells [141] Under stress conditions, the absence of TRIM24 resulted in a rapid decrease in numbers of live cells, whereas TRIM24-expressing cells persisted for twice as long before reaching similar levels.