AKT1 and central nervous system cancer: KAT6A-induced H3K23 acetylation enhances TRIM24 association with chromatin, leading to the upregulation of phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha (PIK3CA) transcription and activation of the phosphatidylinositide 3-kinase (PI3K)/protein kinase B (PKB, also known as AKT) signaling pathway in glioma cells [48].