Considering the complexity of the condition, which involves numerous cellular and organ targets, in this RCT, attention was paid in particular to cytokines (i.e., IL-6, IL-10, TNF-α, TNF-β, and IFN-γ), markers of endothelial dysfunction (i.e., selectin, sICAM, and sVCAM), cardiovascular markers (i.e. PDGF, VEGF, and Flt3L), and “surrogate markers” for adhesion proteins, as fractalkine. Here, CX3CL1 is linked to endothelial dysfunction.