Noteworthy, the use of other drugs, like non‐steroidal anti‐inflammatory drugs (NSAIDs) and cyclooxygenase‐2 inhibitors (COX2i), by the studied RA patients (self‐medication) for declining their pain before RA diagnosis and the direct effects of these drugs on inflammatory conditions and disease‐involved factors, for instance IL‐6 and CXCL9/CXCR3, and our inability to exclude the possible effects of these drugs can be considered as a limitation of this study. Here, CXCR3 is linked to rheumatoid arthritis.