In the current study, for determining the possible prognostic role of IL‐6 in the development of cardiovascular events in the subclinical stages in RA patients, the association between plasma IL‐6 concentration and cardiac biomarker NT‐proBNP and HS‐CRP, CVD predictor algorithms, SCORE and FRS, as well as with CXCL9 and its receptor, CXCR3 was assessed. The gene discussed is CXCR3; the disease is rheumatoid arthritis.