First, the study of Italian patients with HCM found that the variant was significantly associated with an arrhythmic profile leading to more frequent episodes of NSVT, ICD implantation and a higher risk of SCD, and with a milder thickening of the left ventricular wall in probands with MYBPC3:c.913_914del compared to those with other LP/P MYBPC3 variants [10]. The gene discussed is MYBPC3; the disease is Schnyder corneal dystrophy.