Our findings in the Slovenian cohort with the MYBPC3:c.913_914del variant differed from those reported in the Italian study, suggesting that conclusions about the clinical presentation of a specific pathogenic variant should be drawn with caution, given the incomplete penetrance and heterogeneous clinical presentation of variants associated with hypertrophic cardiomyopathy. The gene discussed is MYBPC3; the disease is hypertrophic cardiomyopathy.