Additional mixed pathologies are seen mostly with alpha-synuclein (αSyn) (41–55%) reflecting limbic amygdala-only pathology [58] and cortical pathology in the form of Parkinson’s disease (PD) and dementia with Lewy bodies (DLB), and TDP-43 pathology (33–40%) as part of limbic-predominant age-related TDP-43 encephalopathy neuropathologic changes (LATE-NC) [41, 43]. The gene discussed is TARDBP; the disease is Parkinson disease.