In the obese-MASH model, Pcolce KO mice exhibited a reduction in the expression of PCPE-1 in the liver (Figs. 3D and EV3E), which was also shown to be associated with diminished liver fibrosis in the HFD mice (Figs. 3E,F and EV3F). The gene discussed is PCOLCE; the disease is Hepatic fibrosis.