In contrast to the BAT Pcolce KO mice, liver TG levels were similar between the genotypes in the systemic KO model with dietary obesity (Fig. 3G), with the plasma ALT (Fig. 3H), transcripts for fibrillogenesis, and inflammation shown to be comparable to their littermate controls on respective diets (except for Tgfb1, which showed a slight increase in the KO mice with dietary obesity) (Fig. 3H,I). The gene discussed is TGFB1; the disease is obesity due to melanocortin 4 receptor deficiency.