PCOLCE and fatty liver disease: Consistent with the pathological findings on MASH, it was found that dietary obese mice had developed liver steatosis (Fig. 1G,H), characterized by an increase in their circulatory alanine aminotransferase (ALT) levels (Fig. 1I), liver fibrosis (Figs. 1J,K,L and EV1Q) and inflammatory markers (Fig. 1L), which were also associated with an increase in their PCPE-1 levels in the liver (Fig. 1M).