In this setting, it was found that body weight, BAT and WAT weights, and pathological findings on BAT were comparable between the genotypes compared (Figs. EV2D–F; Appendix Figs. S2A,S2B), while liver fibrosis was ameliorated in BAT Pcolce KO mice compared to littermate control mice in our obese-MASH model (Figs. 2E,F and EV2G,H). This evidence concerns the gene PCOLCE and Hepatic fibrosis.