Studies in rodents and humans showed that circulating PCPE-1 is associated with liver fibrosis (Hassoun et al, 2017; Hassoun et al, 2016) and systemic depletion of PCPE-1 ameliorates fibrosis in the liver in a murine MASH model (Sansilvestri Morel et al, 2022), indicating that PCPE-1 may represent a relevant biomarker as well as a therapeutic target for MASH (Lagoutte et al, 2021). This evidence concerns the gene PCOLCE and metabolic dysfunction-associated steatohepatitis.