Thus, it was found that AAV treatment increased circulatory and liver levels of PCPE-1 under these conditions (Fig. EV2O,P), while HFD led to an increase in liver fibrosis, and Pcolce induction in BAT synergistically augmented liver fibrosis (Fig. EV2Q; Appendix Fig. S2H and S2I). This evidence concerns the gene PCOLCE and Hepatic fibrosis.