The summary of this study are given in Figure S2 and the association of these 10 sKGs with both T2D and ccRCC also supported by some previous individual studies including CDC4233,98,99, SCARB1100–102, VIM103–105, IL1B106–110, GOT2111,112, JUN113,114, TLR4115–118, FN1119–121, TLR2122–124 and CXCL8125–129 as displayed in Fig. 6A. A study claimed that the gene ‘CDC42’ stimulates insulin secretion which is connected to the diabetes-related diseases, such as Diabetic Nephropathy(DN), ccRCC and various cancers98. Here, INS is linked to nonpapillary renal cell carcinoma.