Figure S1B shows that 3 sKGs (CDC42, GOT2, and CXCL8) are downregulated in T2D, while the rest 7 sKGs (TLR4, IL1B, TLR2, FN1, JUN, VIM, and SCARB1) are upregulated, which also supported the proposed results. The gene discussed is CXCL8; the disease is type 2 diabetes mellitus.