From Box whisker plot it was found that seven sKGs (SCARB1, FN1, IL1B, JUN, TLR2, TLR4, and VIM)) were hypomethylated according to β-values (ranging from 0 (that means completely unmethylated) to 1 (that means highly methylated)) which is strong evidence that, seven sKGs were upregulated in ccRCC. The gene discussed is TLR2; the disease is nonpapillary renal cell carcinoma.