Inhibition of sEH has been shown to alleviate oxidative stress in carbon tetrachloride (CCl4)-induced cirrhosis in rats51; reduces portal pressure, liver fibrosis and attenuates hepatic endothelial dysfunction in cirrhotic rats52; and reduce oxidative stress, fibrosis, and electrical remodeling in thoracic aortic constriction mice model53. The gene discussed is EPHX2; the disease is Hepatic fibrosis.