Based on the CHRONOS score, an algorithm for inferring gene knockout fitness effects based on an explicit model of cell proliferation dynamics after CRISPR gene knockout [45], several of the MYC and JUNB gene targets are preferentially essential for MM cells, including lineage-defining TFs such as PIM2 for MYC, and IRF4 for JUNB (Supplemental Fig. 3c) as well as regulatory proteins within the endoplasmatic reticulum, the nucleus, the lysosome, the mitochondria, and the Golgi apparatus (Supplemental Fig. 3d). Here, MYC is linked to Miyoshi myopathy.