The predictive ability of the resulting equation [IC50 = 8577 − (1048 × LZTR1) − (1092 × CUL2) + (167 × MYC)] was confirmed by plotting experimental and calculated IC50 of MZ-1 in a total of six MM cell lines (Supplemental Fig. 5f). Here, CUL2 is linked to Miyoshi myopathy.