BRCA1 and ovarian cancer: BRCA1-deficient ovarian cancer cells exhibited increased transcript levels of MDA5 and RIGI as well as multiple downstream ISGs including IRF3 and IRF7. Interestingly, this finding corroborated our previous work showing increased transcript levels of MDA5 and RIGI in nonmalignant primary FTE cells from BRCA1-mutation carriers, as compared to FTE cells from control patients, following their exposure to periovulatory follicular fluid (13).