Increased expression of ISG15 mRNA was detected in a triple-negative BRCA1-null breast cancer cell line compared to cells transfected with BRCA1. As well, elevated interferon signaling, including ISG15 levels, was observed in an ovarian cancer BRCA1-null cell line compared to BRCA1-transfected cells (62). This evidence concerns the gene ISG15 and ovarian carcinoma.