Immunofluorescence (IF) staining of each group illustrated that 1N11 localizes to tumor vasculature in a β2GP1-dependent manner, showing no localization in tumor-bearing Apoh−/− mice without prior incubation of 1N11 with a 2 to 1 M ratio of β2GP1 (Fig. 1D). Here, APOH is linked to neoplasm.