HFE and hyperinsulinemic hypoglycemia, familial, 4: Apart from the metabolic changes in adipose tissues and adipocytes, it is also necessary to mention that Hfe deficiency or mutation can increase the risk of some hepatic disease (such as hepatic fibrosis and nonalcoholic fatty liver disease, due to the cell damage and iron overloaded in liver tissue) and glucose metabolic disorders (41, 42, 43).