To validate the role of Dock5 in the mediation of liraglutide in vivo, keratinocyte‐specific Dock5 knockout mice (hereafter referred to as cKO), which were bred Dock5 conditional allele (Dock5flox/flox) mice with keratin14‐Cre mice, and their littermate wild‐type (WT) mice were induced to develop diabetes. The gene discussed is DOCK5; the disease is diabetes mellitus.