PRRT2 and skin disorder: They show that (i) the transcriptional signature of WT mouse ear skin when TAR is manifested (i.e., at 6 h after 2 TPA Tx, 24 h apart) shows a strong neutrophil character, as expected; (ii) several of the genes up-regulated in TAR-exhibiting mouse skin are expressed in human inflammatory skin disorders and are involved in regulating PKC activity; and (iii) a transcriptional signature inferred from TAR as it occurs in mouse skin is shared with keratinocytes exhibiting high expression of stress keratins, including KRT17, in human skin disorders.