They show that (i) the transcriptional signature of WT mouse ear skin when TAR is manifested (i.e., at 6 h after 2 TPA Tx, 24 h apart) shows a strong neutrophil character, as expected; (ii) several of the genes up-regulated in TAR-exhibiting mouse skin are expressed in human inflammatory skin disorders and are involved in regulating PKC activity; and (iii) a transcriptional signature inferred from TAR as it occurs in mouse skin is shared with keratinocytes exhibiting high expression of stress keratins, including KRT17, in human skin disorders. This evidence concerns the gene PRRT2 and inflammatory skin disease.