As 178 potential ETV1 target genes have been identified and ETV1 shares binding sites with TBX5, NKX2.5 and GATA4 in atrial myocytes, future studies should focus on elucidating the interplay between ETV1 and other AF transcription factors to regulate calcium handling.48 The gene discussed is NKX2-5; the disease is atrial fibrillation.