rhGH was used based on prior evidence that growth hormone (GH) has thymotrophic and immune reconstituting effects in animals. Because GH might induce hyperinsulinemia which is an undesirable side effect, dehydroepiandrosterone (DHEA) and metformin were added in an attempt to limit the “diabetogenic” effect of GH. Here, GH1 is linked to hyperinsulinism.