Reduced LARP7 levels due to activation of the ATM pathway may contribute to the development of HF, while LARP7 reconstitution in injured hearts may provide myocardial protection.[119] Inflammatory factors S100A8 and S100A9 are involved in autophagy and apoptosis and can regulate these processes in CMs via the MAPK or PI3K‐AKT signaling pathways.[120] In summary, during HF, the whole heart's cellular composition and cell types undergo extensive changes, which scRNA‐seq can detect. The gene discussed is S100A8; the disease is hydrops fetalis.