Recently, Zu et al. found that TRIM22 acts as an E3 ubiquitin ligase and degrades NS1 and NS3 proteins by ubiquitination, thereby inhibiting the infection of other flaviviruses such as ZIKV, DENV and YFV.[29a]Although this conclusion was validated in in vitro experiments, the effect of TRIM22 on flavivirus infection in vivo has not been further explored. The gene discussed is KRAS; the disease is infection.