Succinylation enhances the conversion of 3‐phosphoglycerate (3‐PG) to 2‐phosphoglycerate (2‐PG) by promoting PGAM1 enzymatic activity, resulting in glycolysis, and proliferation in hepatoma cells.[41] Additionally, lysine succinylome analysis revealed 307 differentially modified succinylated sites in 108 proteins, which are involved in various metabolic pathways and cellular processes in human ischemic failing cardiac myofibrils.[42] Similarly, SIRT5 plays a pivotal role in liver disease by regulating protein succinylation. Here, PGAM1 is linked to hepatocellular carcinoma.