SIRT5 and steatosis: SIRT5 depletion in the liver of mice can accelerate liver I/R injury.[17] In contrast, liver overexpression or pharmacological activation of SIRT5 has been shown to exert an obvious hepatoprotective effect against liver I/R injury and steatosis.[25, 26] However, to our knowledge, no previous studies have explored the role of SIRT5 in AILI.