T2D is mainly characterized by impaired insulin sensitivity, leading to β-cell dysfunction.3 In Southwestern Native Americans, KCNQ1, located in an imprinted gene region, is associated with T2D.62 The authors targeted SNPs at the KCNQ1 locus in hiPSCs derived from a Native American patient with T2D, resulting in a functional hemizygous deletion in KCNQ1. The gene discussed is INS; the disease is type 2 diabetes mellitus.