HNF1A and diabetes mellitus: Induced pluripotent stem cells have been derived from a variety of MODY patients.40-42HNF1A mutations, which cause MODY-3, a monogenic form of diabetes, have been studied using SC-islets.43-46 Recent studies used iPSCs from HNF1A-MODY patients or CRISPR/Cas9 to target HNF1A and differentiate the stem cells into SC-derived endocrine cells.