HNF1A and maturity-onset diabetes of the young type 3: In opposition, a different mutation in HNF1A induced insulin hypersecretion and increased calcium signaling.45 A common truncated mutation in HNF1A induced disruptions to the differentiation by interacting with HNF1B, leading to reduced PDX1 and NKX6.1 expression in pancreatic progenitors.46 These studies have added to the existing literature on pathogenesis of MODY-3 and emphasized the importance of studying different mutations within the HNF1A gene.