PDX1 and familial pancreatic carcinoma: MMP9, classified as a gelatinase along with MMP2, has been reported to be involved in the invasiveness of various cancers, including PDACs, through the degradation of many extracellular matrix proteins16, 17 Increased expression of MMP9 has been reported in pancreatic cancer compared to normal pancreatic tissue, with the expression increasing with disease progression to PDACs in Pdx1‐Cre; LSL‐KrasG12D/+; Trp53flox/+ mice.