Overexpression of farnesoid X receptor (FXR), (NSAID)‐activated gene‐1 (NAG‐1), and growth differentiation factor‐15 (GDF15) ameliorates liver steatosis, reduces lipogenesis, and enhances lipolysis and fatty acid β‐oxidation, while concurrently suppressing AIM2 inflammasome activation.23, 126. The gene discussed is NR1H4; the disease is fatty liver disease.