In mice, administration of HFD or methionine/choline deficient diet (MCD) augments hepatic expression of AIM2, caspase‐1, IL‐1β, and IL‐18,122, 123 indicating AIM2 inflammasome likely contributes to the progression of NAFLD and NASH. This evidence concerns the gene AIM2 and metabolic dysfunction-associated steatotic liver disease.