In the cytosol, IRF3 was shown to bind to inhibitor of kappa B kinase beta (IKKβ) and represses IKKβ/NF‐κB signaling, uncovering a non‐canonical role of cytosolic IRF3 in preventing NF‐κB‐mediated inflammation during obesity.90 Here, IRF3 is linked to obesity due to melanocortin 4 receptor deficiency.