The Gram-positive bacterium S. aureus was a frequent colonizer of the skin and mucosae of the human host (44, 45) and was often the cause of SSTIs (46, –, 48); as shown in our mouse skin abscess model, the abscess size arising from all the five ST630 isolates were significantly larger than the USA300-LAC strains. The gene discussed is LCT; the disease is abscess.