Indeed, there is a large body of evidence to suggest that increasing SIRT3 activity has protective effects, which has been shown to be of therapeutic benefit in cell and animal models of cardiovascular, renal, liver and neurodegenerative diseases (Gleave et al., 2017; Morigi et al., 2018; He et al., 2019; Govindarajulu et al., 2021; Trinh et al., 2023). The gene discussed is SIRT3; the disease is neurodegenerative disease.