SIRT3 and neurodegenerative disease: However, SIRT3 levels, and thus activity, declines with age, and is further decreased in pathologies such as cardiac myopathy, fatty liver disease, and neurodegenerative diseases, such as Alzheimer’s, Huntington’s and Parkinson’s disease (Kendrick et al., 2011; Fu et al., 2012; Weir et al., 2012; Yang et al., 2015; Kwon et al., 2017; Yu et al., 2017; Song et al., 2020, 2021; Trinh et al., 2023).