The Elsevier pathway database showed that mechanically regulated genes were associated with aberant bone cell function in several diseases inlcuding ‘osteoclasts function in Osteopetrosis’ (10/19 p = 0.004), ‘osteoclast activation in Rheumatoid Arthritis’ (20/57 p = 0.022), ‘osteoclast activation in postmenopause’ (16/42 p = 0.017), ‘WNT signaling dysregulation in osteoblasts’ (7/15 p = 0.035), ‘osteoclast activation in Psoriatic Arthritis’ (16/47 p = 0.049), and ‘TNF and IL1B induce metalloproteinase synthesis in Osteoarthritis’ (14/38 p = 0.034) (Supplementary Table 4). Here, TNF is linked to osteopetrosis.