Furthermore, Blautia is a common acetate producer in the gut, activating G-protein coupled receptors (GPR41 and GPR43) to inhibit insulin signaling and fat accumulation in adipocytes, promoting the metabolism of unbound lipids and glucose in other tissues, and thereby alleviating obesity-related diseases (28). Here, FFAR3 is linked to obesity due to melanocortin 4 receptor deficiency.