In MPN, hyperactivation of the JAK‒STAT pathway induces the proliferation of myeloid lineage cells and cytokines production, including IL‐1, IL‐6, IL‐8, and TNF, and the alarmin heterocomplex S100A8/A9 [6, 34]. Here, IGKV1D-22 is linked to myeloproliferative neoplasm.