LEP and obesity due to melanocortin 4 receptor deficiency: A similar effect was found in moderate PA, such as 30–60 min/time and 3–5 times per week, which was believed to reduce the total body fat and visceral fat content of children and adolescents (81) and promote the decomposition and reduction of fat mass, significantly increase the level of serum leptin and Adiponectin (ADP) (82), thus reducing the incidence of obesity after sitting for a long time.