The analysis of transcripts also demonstrated that hyaluronan synthase 3, AREG, and HB-EGF, 3 markers linked to inflammation, autocrine proliferation, inflammatory-proliferative skin pathologies such as psoriasis (Cook et al, 2004b; Macleod et al, 2021) or exposure of keratinocytes to Th2 cytokines (De Vuyst et al, 2018) were significantly increased in RHE produced with HEKn cultured in HKS or HKS + HKGE supplements. The gene discussed is AREG; the disease is psoriasis.