MAPK1 and cancer: According to the results of Fig. 5A, these genes were involved in the GO terms “positive regulation of ERK1 and ERK2 cascade,” “fibroblast proliferation,” “cell division,” “mitotic cell cycle phase transition,” and “wound healing.” Additionally, the overlapping DEGs were enriched in the following pathways: “Rap1 signaling pathway,” “FoxO signaling pathway,” “p53 signaling pathway,” “Ras signaling pathway,” “pathways in cancer,” “MAPK signaling pathway,” as well as “PI3K-Akt signaling pathway” (Fig. 5B).