In comparison to levels in control tissues, the expression levels of CCNB1, EGFR, BTG1, as well as TP63 were evidently lower in the keloid tissues (P < 0.05), while the expression levels of E2F8 as well as IGF1 were evidently higher in the keloid tissues (P < 0.05, Fig. 8). Here, E2F8 is linked to keloid.