Fibrinogen gamma chain: Major function in homeostasis, significantly higher expression in OSCC compared to healthy controls.α-Defensins 1–3: Major constituent of azurophilic granules of neutrophils, not expressed in normal mucosa, their levels rise in physiological states to exhibit innate immune defenses against infectious diseases including epithelial cancers.•Acts as an important predictor linking inflammation, angiogenesis and cancer. This evidence concerns the gene FGG and cancer.