PMF, post-ET, and post-PV MF were found to have a higher JAK2 V617F allele burden[31] and genetic alteration marker changes, such as TET2, ASXL1, IDH, IKZF1, LNK, EZH2, DNMT3A, NF1, SUZ12, SF3B1, and SRSF2, than ET and PV [32]. This evidence concerns the gene JAK2 and acquired polycythemia vera.