TLR4 was elevated only when PV, ET, and MF were grouped as MPN (Figure 1(c)), while TLR3, 7, and 9 were not significantly elevated from controls Supplementary figure 2 (since only 12 MPN patients were screened for TLR 3, 7, 9, an large cohort studies will be necessary to confirm these findings). Here, TLR4 is linked to acquired polycythemia vera.