TLR4 was elevated only when PV, ET, and MF were grouped as MPN (Figure 1(c)), while TLR3, 7, and 9 were not significantly elevated from controls Supplementary figure 2 (since only 12 MPN patients were screened for TLR 3, 7, 9, an large cohort studies will be necessary to confirm these findings). Here, TLR3 is linked to essential thrombocythemia.