F2R and cancer: In the last category, cancer-related factors, we note that cancer cells themselves induce a procoagulant state through the production of clotting factors (mainly tissue factor (TF)), proinflammatory cytokines, and increased expression of thrombin receptors, as well as endothelial activation induced by the direct interaction of tumor cells with the vascular endothelium, triggering the release of proinflammatory and procoagulant molecules [3].