PFKM and amyotrophic lateral sclerosis: The rate-limiting enzyme of the glycolysis is represented by the phosphofructokinase-1 (PFK1), whose inhibition leads to an increase in glycogen synthase activity and glycogen accumulation in skeletal muscle, which is in fact a characteristic of a muscle subjected to endurance training (Vestergaard, 1999), but also a characteristic of ALS mice (Palamiuc et al., 2015) (Figure 1, left panel).