BRAF, NRAS and TERT mutations are present in more than 66% of melanomas; a study performed in 2020 measuring ctDNA levels harboring these mutations in 19 different patients with late-stage melanoma concluded that detectable levels of ctDNA had a shorter PFS and shorter median time for disease progression at 50 days compared to 146 days for patients that did not have detectable ctDNA (Figure 2A) (Marczynski et al., 2020). The gene discussed is TERT; the disease is melanoma.