CD4 and neoplasm: Furthermore, the results imply that anti-angiogenic drug treatments may enhance the efficacy of immunotherapy (Khan and Kerbel, 2018); Another sequencing work targeting vascular cancer-associated fibroblasts (vCAFs) subgrouping reported tumor-infiltrating CD4 regulatory T cells performed high correlation with immune suppression (Zhang et al., 2020); Additionally, we are pleased to see direct comparisons of treatment failures and successes.