An indirect interaction between SCN9A and CACNA2D1 may exist through LAT1 (SLC7A5) as a common regulator of both; indeed, CIP can be present in patients with CACNA2D1 variants as a part of a more syndromic and severe neurodevelopmental disorder (Dahimene et al., 2022). The gene discussed is CACNA2D1; the disease is neurodevelopmental disorder.