As key regulatory genes influencing the formation of collagen fibers, COL1A1 and Collagen TypeIII Alpha1 Chain (COL3A1) were found to be downregulated by comparing the hip joint capsule of DDH and the control tissue using high-throughput sequencing, which was suspected to be one of the factors leading to joint capsule relaxation due to the loss of collagen fibers and fibroblasts (Yang et al., 2022). The gene discussed is COL1A1; the disease is Hip dysplasia.