Due to the important role of the COL27A1 variant in STLS, some of the major skeletal features associated with Steel syndrome, such as shortened body length, scoliosis, and altered skull shape, were observed in COL27A1 knockout mice, although DDH was not present (Gonzaga-Jauregui et al., 2020), so the role of COL27A1 in human bone development deserves further study. This evidence concerns the gene COL27A1 and scoliosis.