In addition, in a study of 12 patients with Arthrochalasia Ehlers-Danlos syndrome (aEDS), the majority (10/12) of patients had total or partial loss of COL1A1 or COL1A2 exon 6, five of whom underwent hip joint surgery. The gene discussed is COL1A1; the disease is Ehlers-Danlos syndrome, arthrochalasia type.