Various solute carriers and transporters are associated with epilepsy [54], and the severity in Case 2 can be explained by an additional pathogenic variant in SLC22A17, a target gene that is likely to be modulated by RTEL1-TNFRSF6B overexpression via hsa-miR-3569-3p. The gene discussed is TNFRSF6B; the disease is epilepsy.