The centroid secondary RNA structure prediction for wild-type and mutant RTEL1-TNFRSF6B showed an increase in MFE and circular conformation upon mutation, whereas other missense variants of RTEL1-TNFRSF6B, which are reported as pathogenic or likely pathogenic in the ClinVar database and which are associated with telomere biology disorders, including dyskeratosis congenita, did not reveal a significant change in the conformation of the RTEL1-TNFRSF6B nor in MFE compared to the wild type (Supporting Information 9). This evidence concerns the gene TNFRSF6B and dyskeratosis congenita.