In this report, it was shown that FAK and PVR are coexpressed in tumor cells in HGSOC and that the combination of FAK inhibitors and anti-TIGIT antibodies maintains elevated TIL levels, decreases TIGIT-positive Tregs, prolongs survival, increases CXCL13, and leads to the formation of tertiary lymphoid structure in the ovary (98). The gene discussed is PVR; the disease is neoplasm.