Following tamoxifen treatment (Supplementary Figure S5), mice did not succumb to fatal autoimmunity, but like Sin3a−/−Foxp3cre mice, they had massive sLNs (Supplementary Figure S6A) with pronounced follicles and germinal centers and developed PMN infiltrates and airway cuffing in the lungs (Supplementary Figure S6B). Here, SIN3A is linked to Autoimmunity.