IL17A and metabolic dysfunction-associated steatohepatitis: In methyl choline-deficient diet (MCD)- or high fat diet (HFD)-induced MASH models, the Th17/IL-17 axis increased hepatic CXCL-10 via an NF-κB/p65-dependent mechanism (Figure 1), promoting the recruitment of inflammatory macrophages and T cells (145, 146).