Importantly, a specific single nucleotide polymorphism in the patatin-like phospholipase domain-containing protein 3 (PNPLA3) gene (rs738409) is strongly correlated with MASLD, disrupting the normal regulation of hepatic triglyceride lipolysis and causing fat accumulation in the liver (12, 13). The gene discussed is PNPLA3; the disease is metabolic dysfunction-associated steatotic liver disease.