SREBF1 and Hepatic steatosis: In an experimental ASH model, genetic ablation of the IL-17RA in steatotic hepatocytes downregulated TNFRI, sterol regulatory element-binding proteins 1/2 (SREBP1/2), and 7-dehydrocholesterol reductase (DHCR7), leading to protection against hepatic steatosis and HCC development (169).