We further validated the sex-dependent influence of IL-22 in HFD-induced MASLD models and demonstrated that a deficiency of IL-22 receptor signaling (Il22ra1-/- mice) exacerbated liver injury, hepatocyte death, lobular inflammation, and the advancement of MASH-related fibrosis in female but not male mice (277). Here, IL22 is linked to metabolic dysfunction-associated steatotic liver disease.