However, given the important roles that IL-17 and IL-22 play in MASLD and with the increased awareness of the key role of sex-dependent differences observed at the level of these cytokines and progression of MASLD, recent studies integrated males and female to better investigate the contribution of sexual dimorphism to MASLD, and more specifically with respect to the IL-17/IL-22 levels and functions. This evidence concerns the gene IL22 and metabolic dysfunction-associated steatotic liver disease.