Immunostaining was negative for Cytokeratin 7 (CK7), positive for Cytokeratin 20 (CK20) and Special AT-Rich Sequence-Binding Protein 2 (SATB2), and negative for estrogen receptor (ER) and Paired Box Gene 2 (PAX2), leading to a diagnosis of metastatic recurrence of small bowel cancer. This evidence concerns the gene ESR1 and small intestine carcinoma.